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It's important to distinguish between multi-dose pens (Ozempic, Victoza, Saxenda) and single-dose autoinjectors (Wegovy, Trulicity, Mounjaro, Zepbound)

Why Do GLP-1 Medications Cause Side Effects

doi:10.1111/bpa.12388 90

2017 [cited 2025 Jan 27]

We next identify and map sites of cholesterol high occupancy and residence time on active versus inactive GLP-1Rs using coarse-grained molecular dynamics (cgMD) simulations, followed by a screen of key residues selected from these sites and detailed analyses of the effects of mutating one of these residues, Val229, to alanine on GLP-1R interactions with cholesterol, plasma membrane behaviours, clustering, trafficking and signalling in pancreatic beta cells and primary islets, unveiling an improved insulin secretion profile for the V229A mutant receptor