cigarette smoke induces cytoplasmic p53 accumulation smoke-induced toxicity consequences of intracellular iron dysregulation and ferroptosis Tobacco smoke exposure is a

An unexpected role of cholesterol sulfotransferase and its regulation in sensitizing mice to acetaminophen-induced liver injury

In conclusion, this is the first study to offer direct evidence that smoking during pregnancy can exacerbate drug-induced liver injury in offspring mice later in life by modulating hepatic miRNAs

To date, it is the gene with the highest correlation to human tumors identified, and the understanding of TP53 has changed from oncogene to tumor suppressor gene [1]

Therefore, shifting the balance between these signaling pathways can determine the outcome between cell death and survival in irradiated cells [15]

A.et al (2020b)

More importantly, the mutational status of p53 does not significantly affect the outcome and long-term survival of patients treated with Gendicine [171, 172]