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Participants Participants from the Netherlands Twin Register [NTR: n = 21 939, mean age 40.8, standard deviation (SD) = 16.9, 62.6% female] and the Avon Longitudinal Study of Parents and Children (ALSPAC: n = 9086, mean age 33.2, SD = 4.7, 100% female)

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Fortunately, traditional cigarette smoking has been steadily declining: according to the World Health Organisation (WHO), global smoking rates have dropped from 33% in 2000 to 20% in 2024

4 weeks Plasma suPAR is a stable inflammatory biomarker that helps predict development of diseases ranging from diabetes to cancer in smokers