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4 EVALUATION AND SCREENING The American College of Obstetricians and Gynecologists recommends that clinicians ask about tobacco use (along with secondhand smoking) before pregnancy, throughout pregnancy, and during postpartum periods, and advise patients regarding the significant perinatal risks and the importance of quitting tobacco or nicotine use in any form, including e-cigarettes and vaping

It was to be applied science, rather than theoretical science

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National Toxicology Program released a Strategic Roadmap advising regulatory agencies to provide more human-relevant toxicology data while reducing the use of animals. Currently, the CDC has numerous options for studying vaping without animals, including in vitro assays, in silico approaches, computational chemistry and a range of sophisticated tissue models that include 3D organoids and organs-on-chips