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Dermatology guidance emphasizes identifying the cause as the first step to effective treatment

Orforglipron is a small-molecule (non-peptide) oral GLP-1 receptor agonist

Both medications affect similar hormone pathways that control appetite, digestion, and blood sugar

Additional research on discontinuation is needed, including the role of shortages, adverse events, and costs

Months of lower body weight produce lasting benefits including improved insulin sensitivity, reduced hepatic fat, decreased inflammatory markers, and potentially improved cardiovascular remodeling