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demonstrated that nicotine mediated activation of 7 receptors in mice promoted the upregulation of receptor activator of nuclear factor kappa- ligand (RANKL) and inhibited osteoprotegerin OPG expression, consequently promoting osteoclast activation and bone resorption [55]

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Subst Use Misuse

nicotine affects areas responsible for memory, feelings, thoughts, and decision-making processes and can cause serious damage to mental and physical health, leading to nicotine addiction

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