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Some studies demonstrated a higher risk of cancer in female users [odds ratio (OR) ranging between 3.2 and 45.89] compared to males in the same study (OR ranging from 2.7 to 9.33)

Well, it is simple

Oncotarget 8 , 112132112144 (2017)

Which of the following agents is NOT recommended in combination

Thats because the effects of long-time smoking can take up to 20 years to be cleaned

Encourage smoking cessation and drinking alcohol according to NHS advice
