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The link between smoking and chronic pain is due to the ability of nicotine and other chemicals to: Narrows blood vessels, reducing blood flow to the muscles, bones and organs Decrease the rate of exchange of carbon dioxide and oxygen in the blood Slow healing Increase blood pressure Increase feelings of fatigue Chronic pain is considered that lasts more than three months

In addition, the potential genetic changes in the nicotinic receptor expression with advancing age may also account for the moderate nicotine dependence found in heavy smokers

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These cells are almost as healthy as those in never smokers, with much less genetic damage from smoking

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