cigarette smoke induces cytoplasmic p53 accumulation sidestream smoke-induced cellular senescence and the protective role of histone H2AX The mutagenic effect of tobacco
Description
Wtp53 acts as a DNA sequence-specific transcriptional regulator that activates upon sensing various stress signals, and post-translational modifications can regulate its activation [45]

It works particularly well for those who prefer a noticeable tobacco profile but still want smoothness and control

doi: 10.3389/fphys.2014.00166

doi: 10.1038/sj.onc.1209579

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p38 kinase mediates UV-induced phosphorylation of p53 protein at serine 389
