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So far, studies have found little evidence of compensation, but smokers do seek out other sources of nicotine.(109) Having lower-risk nicotine-containing products, such as nicotine replacement therapy (NRT) or e-cigarettes, readily available to smokers of VLNC cigarettes will likely be essential for the strategy to succeed.(110) A simulation model found that reducing cigarettes nicotine content to minimally addictive levels would lead to a substantial reduction in tobacco-related mortality, despite uncertainty about the effects on smoking behaviors.(111) A key component of the reduced nicotine strategy is to identify the appropriate regulatory approach to alternative sources of nicotine such as e-cigarettes.(112) Because they do not burn tobacco, e-cigarettes should pose less risk to users than cigarette smoke

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All volunteers were asked to smoke up the whole amount of one cigarette, and all cigarettes were of the same brand in order to standardize the nicotine content (0.6 mg per one cigarette)

One can also not understate the importance of freedom of speech to the betterment of men and women themselves, outside of just the political realm

[1] 7080% of nicotine is metabolized by the liver, primarily into cotinine