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Indeed, nicotine inhalation (0-64 mg/ml) showed a dose-dependent increase in the amount of coughing and airway obstruction in non-smokers, which may be a consequence of the stimulation of afferent nerve endings in the bronchial mucosa by nicotine, which in turn triggers parasympathetic cholinergic pathways leading to bronchoconstriction [62]

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[DOI] [PubMed] [Google Scholar] 4.Lombard H