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This is not possible with humans, as it would be unethical to make people smoke

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Although nicotine levels vary significantly across the spectrum of types, the fact remains that nicotine use during adolescence has been shown to impact learning, attention span and proneness to addiction

Effects of bidi smoking on all-cause mortality and cardiorespiratory outcomes in men from south Asia: an observational community-based substudy of the Prospective Urban Rural Epidemiology Study (PURE)