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Nicotine tests aren't as simple as testing for nicotine - there are a variety of tests that can find the metabolites of nicotine, such as cotinine, that can be found in urine tests for several weeks after giving up smoking

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It has been reported that nicotine induces the production of growth factors such as vascular endothelial growth factor (VEGF), Platelet-derived growth factor (PDGF-BB), and Fibroblast growth factor (FGF-2) from VSMCs, and that PDGF-BB and FGF-2 promoted the proliferation of VSMCs [29, 50, 51, 52]

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