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N Engl J Med 334(3):150154 Chalon S et al (2000) Nicotine impairs endothelium-dependent dilatation in human veins in vivo

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Indeed, nicotine triggers oxidative stress in the testis, resulting in a global alteration of testis function, with a decrease in testosterone level, lower epididymal sperm number and viability, and increased levels of apoptosis in spermatogonia and spermatocytes [53,54,55,56]