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Individuals with higher BMIs may retain nicotine longer than those with lower BMIs

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High-strength pouches in the 8 to 20mg range can cause a burning sensation or nausea in lighter users, which not only feels unpleasant but can disrupt the passive, invisible experience that makes pouches so appealing

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Another study highlighted a significant increase in the clearance of orally administered clozapine in smokers respect to non-smokers [50]

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