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Smoking and secondhand smoke kill over 22,000 people each year in New York State

For cigarettes, the rate was 0.7% (95% CI: 0.7, 0.7)/0.5% (95% CI: 0.5, 0.5)/0.6% (95% CI: 0.5, 0.7) among junior high school students, and 2.0% (95% CI: 1.9, 2.1)/0.9% (95% CI: 0.9, 0.9)/1.5% (95% CI: 1.4, 1.6) among high school students

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In particular, the suppression of IL-12 production, a potent inducer of Th1 responses, may potentially contribute to blunted host defense mechanisms against infections mediated by DCs exposed to nicotine

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It is acknowledged that these factors can influence health behaviors and outcomes, and future studies should aim to include these variables more explicitly