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Its original vision statement was to enhance natural tobacco components that may have potential to either reduce or mitigate the biological activity of tobacco-burning cigarettes.43 This statement was later amended as follows: to provide smokers with products which contain biological activity mitigants.42 Biological activities targeted included reducing nitrosamine levels, nitric oxide levels, carbonyl groups, Ames activity (a measure of mutagenic and carcinogenic potential), ciliostatic and cytotoxic response, and possibly free radical concentrations.44 Numerous RJ Reynolds documents showed that the company considered adding mitigants, such as beta-carotene, to cigarettes.42 , 47 56 Mitigants were defined as antioxidants and other compounds for free radical reduction (i.e., reduction of the concentration of free radicals)57 , 58

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Facts: What Science Says About Disease Transmission Several misconceptions exist regarding disease transmission through shared smoking implements: Myth: The heat from smoking kills all germs Fact: While heat can inactivate some pathogens, the temperature at the mouthpiece of most smoking devices isn't consistently high enough to sterilize the surface

"I didn't know anyone whose parents didn't smoke." Martin owns a tavern in Hutchinson, Kan., which still permits smoking it was grandfathered in under a state smoking ban

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