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Furthermore, clinical trials have shown that standard NRT doses are inadequate for rapid metabolizers of nicotine (i.e., those who inactivate nicotine to cotinine and then to 3-hydroxycotinine [3-HC] more quickly than others due to genetic variation affecting the activity of the hepatic enzyme CYP2A6) [20, 25]

environmental and health groups are just now appreciating the seriousness of the butt problem, from bio-accumulation of poisons up the food chain to damage to commercial fisheries and water supplies

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Traditional freebase nicotine delivers a slower nicotine hit than cigarettes, however, nic salt e-liquids commonly found in disposable vapes, provide a faster and smoother hit that mimics the absorption rate of cigarettes

Subjects/Methods A randomized controlled trial with 12-month follow-up from 2018 to 2022 was conducted with participants ( N = 305) who reported smoking at least five cigarettes per day for the last year and interest in quitting initially recruited from the Memphis, TN, USA area

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