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Although evidence on the health effects of smoking has been widely reported, few attempts have evaluated the doseresponse relationship between smoking and a diverse range of health outcomes systematically and comprehensively

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The results indicated that, under this highly unlikely scenario, the tipping point occurs at a 3,500% increase in initiation rates (Table 3)

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In addition, CS induced region-specific shifts in digestive tract microbiota, reducing beneficial genera such as Clostridium and Turicibacter while increasing harmful genera like Desulfovibrio and Bilophila