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This dysfunction is a critical indicator of cardiovascular damage and is considered an early predictor of cardiovascular events and prognosis in smokers [16]

Croninger, Experimental Production of Carcinoma With Cigarette Tar, Cancer Research 13 (1953): 855864

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Certain regions of the brain, including the hippocampus, the cerebellum, and the cerebral cortex, have higher levels of cannabinoid receptors

This distinction is especially important for adolescents and young adults who may never otherwise have smoked cigarettes