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This study suggests the possibility of harm reduction if e-cigarette use were completely substituted for tobacco smoking, although the study was not designed to answer this question and selection into the cohort for nonusers was unclear

Preventing Tobacco Use Among Youth and Young Adults: A Report of the Surgeon General

Although more challenging and costly, ALI better recapitulates physiological conditions of the pulmonary barrier and all phases (gaseous, semi-volatile and particulate) and components of the test aerosol are included in the analysis [18]

The latter can further cross-react with proteins in cell medium which may reduce their bioavailability and underestimate their toxicity

NCHS Data Brief, no 475

Ask if they have heard of vaping or if they have seen their friends using e-cigarettes