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Nicotine addiction: neurobiology and mechanism

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Many tobacco users continued to use smokeless tobacco, such as chewing tobacco, possibly due to the lack of areas to smoke

However, this regenerative response appears dysregulated, as reflected by abnormal growth patterns, emphasizing that persistent injury may drive both progenitor activation and exhaustion over time ( MSCs and EVs demonstrated potent immunomodulatory effects, reducing inflammatory infiltration and collagen deposition while normalizing organoid growth

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