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Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins

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16 Additionally, when intracellular cholesterol is excessive, sterol regulatory element-binding protein cleavage-activating protein (SCAP) undergoes conformational changes, preventing SREBP2 from being cleaved in the Golgi apparatus and entering the nucleus to activate target gene transcription
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Chandramani-Shivalingappa, Colin Van Westphal, R
