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One brain system frequently implicated in the reinforcing effects of drugs is the mesolimbic dopamine system, which includes the ventral tegmental area, the nucleus accumbens, and the prefrontal cortex (see figure 3)

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Since less than 10% of its clearance is attributed to vareniclines metabolism, it is anticipated that agents affecting the CYP450 system will have no effect on its pharmacokinetic profile

[PubMed: 12920697] Meyers CD, Kamanna VS, Kashyap ML

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