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These combined effects create a perfect storm for gastroesophageal reflux, explaining why smokers have significantly higher rates of GERD and more severe symptoms

Chem Res Toxicol 11:559603 International Agency for Research on Cancer (2006) Smokeless tobacco and tobacco-specific nitrosamines

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The risk of using NVPs needs to be weighed against the risk of long-term smoking in people who have not been able to quit with first-line treatments (TGA-approved pharmacotherapies and behavioural support)

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