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These labels are so problematic that the Food and Drug Administration has required Santa Fe Natural Tobacco Company, the maker of Natural American Spirit cigarettes, to remove the terms natural and additive-free from its product labels, advertising and promotional materials because they constitute reduced harm claims, which are banned without agency approval

They compared nicotine-containing e-cigarettes to non-nicotinecontaining e-cigarettes

E-cigarette abstinence rate in the varenicline group was 34.3%, significantly higher than the abstinence rate of 17.2% in the placebo group

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Tobacco and cigar smoke embed into surfaces