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These microbial changes correlated with smoking frequency and activated pathways related to respiration and pathogenicity, indicating that CS exacerbated RAS through microbial modulation [58]
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Reduced nicotine content cigarette advertising: How false beliefs and subjective ratings affect smoking behavior

Cellulases and hemicellulases secreted by microorganisms break down cell wall components (Zhao et al., 2025), improving processability, combustibility, and hygroscopy

Since they are totally nicotine-free, they wont do anything to stop the physical withdrawal symptoms
