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SEPTEMBER 2018 Launching full scale e-cigarette messaging effort under The Real Cost campaign brand MAY 2018 Sent warning letters to companies misleading kids with e-liquids that resemble childrens food products Requested critical product information from companies about the youth-appeal of their e-cigarettes APRIL 2018 Unveiled Youth Tobacco Prevention Plan Sent warning letters to retailers who illegally sold JUUL to underage youth Requested critical information from JUUL Labs on marketing and research related to youth initiation and use Provided update on provisional substantial equivalence review process MARCH 2018 Published three advance notices of proposed rulemaking for public comment: Tobacco Product Standard for Nicotine Level of Combusted Cigarettes Regulation of Flavors in Tobacco Products Regulation of Premium Cigars DECEMBER 2017 Launched Every Try Counts public education campaign to encourage adult smokers trying to quit cigarettes NOVEMBER 2017 Launched This Is Our Watch program to educate retailers SEPTEMBER 2017 Expanded The Real Cost campaign to include messaging on e-cigarettes JULY 2017 Announced FDAs Comprehensive Plan for Tobacco and Nicotine Regulation Additional Resources August 2018: FDA In Brief: FDA takes steps to improve efficiency, transparency of tobacco product application review process as part of comprehensive framework to reduce the disease and death related to tobacco products June 2018: Upcoming Tobacco Product Listing Deadline June 30: What Does the Deadline Mean to You, and How is FDA Helping You Comply

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107 In animal studies, even secondhand smoke exposure had numerous negative effects on bones, including decreasing bone mineral content and density, inhibiting new bone formation while increasing bone resorption, decreasing the thickness of the hard outer layer (cortex) of the bone, and producing weaker, more easily fractured bones