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Thus, HDAC5 overexpression promotes the production of inflammatory cytokine, and HDAC5 depletion inhibits the production of inflammatory cytokine

These features of senescent cells are identified as the emerging hallmarks and enabling characteristics of cancer [24]

In light of our previous work connecting Nrf2 activation to an immunosuppressive tumor immune microenvironment for smoking related cancers, it is likely that this pathway dominates these tumors over the long run

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Stroke 26 (8), 14091414

Genes upregulated in smoke exposed tumors mapped to GO pathways related to: (1) negative T cell selection, (2) regulation of NK cell mediated immunity and (3) negative regulation of lymphocyte mediated immunity among others (Supplemental Table XX)