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Description
The results indicate that PUF-8 interacts specifically with wild-type gld-2 PBE ( gld-2 PBE wt ) and a positive control, hunchback NRE ( hb NRE), in yeast three-hybrid assays (Figure 2C and Supplementary Figure S1)

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Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M, and Butler PC

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And on April 1, the Food and Drug Administration (FDA) approved Foundayo (orforglipron), a pill for adults with obesity or who are overweight and have a weight-related medical condition