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These increased inflammatory factors and chemokines leads to further infiltration of immune cells into the respiratory tract, resulting in dysfunctions of fibroblasts, goblet cells, and epithelial cells, ultimately leading to emphysema, mucus accumulation, inflammation, and pulmonary fibrosis [52]

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Mice reproduce just 20 days after mating, according to Orkin and can produce as many as 10 litters of babies in a single calendar year