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Participant characteristics, methodology, and findings are available in Appendix 3 (at www.cmaj.ca/lookup/doi/10.1503/cmaj.241584/tab-related-content)

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We chose this coding because (a) bupropion may have unique effects on symptoms, (b) the coding allowed us to examine the effect of the combination of bupropion and nicotine lozenge (through the interaction of the bupropion effect and the nicotine replacement therapy effect), and (c) it maintains orthogonality of effects

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