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Furthermore, clinical trials have shown that standard NRT doses are inadequate for rapid metabolizers of nicotine (i.e., those who inactivate nicotine to cotinine and then to 3-hydroxycotinine [3-HC] more quickly than others due to genetic variation affecting the activity of the hepatic enzyme CYP2A6) [20, 25]

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The Fagerstrm test for nicotine dependence: a revision of the Fagerstrm tolerance questionnaire

Q: What other important OSH functions have been lost

At this visit, participants will also receive brief behavioral support, provide a venous blood sample (10 ml) to determine plasma cotinine levels, undergo an exhaled CO test, and complete several questionnaires (see Fig
