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Table 1: Mortality and Adjudicated Nonfatal Serious Cardiovascular Events in the Placebo-Controlled CHANTIX Trial in Patients with Stable Cardiovascular Disease A meta-analysis of 15 clinical trials of 12 weeks treatment duration, including 7002 patients (4190 CHANTIX, 2812 placebo), was conducted to systematically assess the cardiovascular safety of CHANTIX

doi: 10.1590/s0034-89102006005000048

The Journal of Clinical Investigation, 120(6), 18001803

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Phosphodiesterase-4 (PDE4) inhibitors and statins Phosphodiesterase 4 (PDE4) inactivates adenosine cyclophosphamide and guanosine cyclophosphamide and is the main PDE isoenzyme in cells involved in inflammatory airway diseases such as COPD