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Certainly, p53 can mediate HBx protein inactivation through MDM2-dependent ubiquitin degradation and even seven in absentia homolog 1 (Siah-1) protein-dependent proteasomal degradation 66,67

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In another p53-null HCC line, the cell growth of Hep3B cells can be inhibited by melatonin (a hormone for regulation of circadian rhythms), which can promote the expression of several proapoptotic target genes (p21 and BAX) of p53 146

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