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Inflammasome assembly leads to caspase 1-dependent release of proinflammatory cytokines IL-1 and IL-18 as well as to gasdermin D (GSDMD)-mediated pyroptotic cell death, facilitating the extracellular release of IL-1 and IL-18 45)

Evidence base The evidence synthesis identified 11 studies that enrolled first-degree relatives of patients with pulmonary fibrosis (5, 13, 2022, 24, 40, 41, 131133) (Figure E16 and Table E6)

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