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Discussion The three themes and CLDs (sub-systems and system-archetypes) have helped to illustrate the dynamics of the interaction between the social determinants of NCDs and tobacco and alcohol use in Nepal

It is now illegal for a retailer to sell any tobacco product including cigarettes, cigars and e-cigarettes to anyone under 21

20 The release of hormones such as norepinephrine, dopamine, serotonin and -aminobutyric acid by the central nervous system influences brain chemicals that suppress eating and increase metabolic rate (such as pro-opiomelanocortin and cocaine-amphetamine-regulated transcript) as well as those that suppress eating and decrease metabolic rate (such as neuropeptide Y, Agouti-related peptide, melanin-concentrating hormone, and orexin)

528 : RR = OR/(1 p 0 + ( p 0 OR)), where p 0 is the control event rate (or baseline risk), which leads to the following: Prior to conducting the pairwise and network meta-analyses, we applied a natural logarithm transformation to the effect sizes

Abstinence from smoking can potentially delay the onset and slow the progression of diabetes-related complications, ultimately improving quality of life (Campagna et al., 2019)