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Genetic variation contributes to initiation, regular smoking, nicotine dependence, and cessation

By stimulating catecholamine release (particularly norepinephrine), nicotine encourages the breakdown of stored fat (lipolysis) and shifts the body toward using fatty acids as an energy source

He worked irregular hours, often staying up late and sleeping in short bursts

As he hypocritically seduced American women into smoking, he was trying to wean his own wife from the nasty habit, Chernow continues

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