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2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Indeed, HCV has a strong ability to induce genomic instability and aneuploidy of hepatocytes, because the ways of its replication had affected the homeostasis of MDM2p53 axis

Czabotar PE, Lessene G, Strasser A, Adams JM

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Therefore, the upregulation of these genes by p53 possibly serves to sensitise cells to apoptosis by cytotoxic T cells and natural killer (NK) cells, which can express the ligands for death receptors

Dixit, U
