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Biological causes: Tobacco use induces neurochemical changes through stimulation of nicotinic acetylcholine receptors, which prompt the release of neurotransmitters that produce pleasure and satisfaction, according to the third chapter of the book Neurobiology of Addictions published in 2016 by the Oxford University Press

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And nicotine itself may not be so harmless

Other diacetyl stand-ins have also been shown to cause respiratory damage in animal models