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Description
Increased P53 suppresses the transcription of cell cycle genes, and this indirect repression of cell cycle genes by P53 is mediated through P21 [6, 35, 36]
microRNA-34a overexpression will increase p53 acetylation and transcription, which leads to the diminishment of sirtuin 1 (SIRT1) in the NAFLD liver

December 3, 2015

KEAP1 +/+ and KEAP1 fl/fl clones A, D, E, and F were provided by Dr
Chen H, Wang X, Yan X, Cheng X, He X, Zheng W

Similar to wtp53, post-transcriptional modifications such as phosphorylation, acetylation and ubiquitination can also regulate the level of mutp53
