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Are weight loss drugs safe

The evidence is strong: an individual patient data meta-analysis showed a 39% reduction in decompensation risk in compensated cirrhosis, and the PREDESCI trial showed roughly a 40% reduction in first decompensation over 2 years

Do these in sequence not all at once, and not out of order

In addition, the cross-sectional nature of the interviews did not allow an exploration of changes over time (i.e., trajectory analysis)

Consistent with these findings, Hansen et al

Most individuals start to notice a reduction in appetite and may begin to experience gradual weight loss within 2 to 4 weeks of starting the medication