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Nausea and vomiting can also occur

Toxic mechanism Nicotine binds stereoselectively to nicotinic acetylcholine receptors (nAchRs), which are pentameric ligand-gated ion channels (LGICs), localised in the peripheral and central nervous system, autonomic ganglia, sympathetic and parasympathetic nervous system, and skeletal neuromuscular junctions 10 , 23

A comprehensive and integrative model of nicotine addiction should consider the different dimensions of nicotine in cognition, emotion, and behavior

J Psychopharmacol 25:14851495 Wang HA, Liang HJ, Ernst TM, Oishi K, Chang L (2020) Microstructural brain abnormalities in HIV + individuals with or without chronic marijuana use

Room Note -Pleasant

This is refined and elegant so don't douse yourself and go offend others with it