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Passive exposure to exhaled vapour, particularly in enclosed environments, introduces nicotine, propylene glycol, aldehydes (e.g

Some flavorings in the vapor, such as diacetyl, are associated with serious lung diseases, and formaldehyde, a known carcinogen, is also a potential component

Toxins reach high levels quickly in enclosed spaces like cars or small rooms

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Anti-citrullinated protein antibodies and citrullination A long time ago RA sera were revealed to specifically react to filaggrin (found physiologically in keratin), which has been proven to be a citrullinated protein