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This increase coincided with a continued reduction in current smoking prevalence, with no evidence that this decline is levelling

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Shares of tobacco companies were seemingly unaffected by the announcement, with Philip Morris stock flat in premarket trading and shares of British American Tobacco up slightly despite a drop in the broader market

The struggles of the company that makes VLN cigarettes, 22nd Century, embody larger challenges faced by advocates who have long believed slashing nicotine levels could save millions of lives