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Network pharmacology studies have indicated that it can regulate lipid metabolism-related pathways to treat diabetic nephropathy [153]

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488,489,490 These inhibitors are capable of specifically targeting categories, subtypes, and structural domains, 491 potentially providing more pronounced benefits in terms of efficacy, safety, and tolerability

doi: 10.3238/arztebl.m2021.0214

Indeed, depletion of CDK2 or inhibition of CDK2-kinase activity in combination with CDK4/6-inhibitors blocked proliferation of CDK4/6-inhibitor resistant cancer cells (111, 141, 158161)

From the 6 patients with thyrotoxicosis that were followed post-discharge, all had normal thyroid function 1.5-2 months later and were negative to thyroid autoantibodies and 3 of them had ultrasound and CT scans suggestive of subacute thyroiditis