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Pharmacopeias, the percentage of S -isomers in nicotine must be higher than 99 percent.24 45 These statements, claiming superior drug-like properties, could provide a basis for FDA to categorise these products as drugs

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Shared gray matter alterations in subtypes of addiction: a voxel-wise meta-analysis

20 Other neurotransmitters that may be involved in nicotine addiction are the hypocretins, neuropeptides produced in the lateral hypothalamus that regulate the stimulatory effects of nicotine on reward centers in the brain and modulate self-administration of nicotine in rodents

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Further demographic and substance use data are available in Table 1