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PMID: 25170798 pubmed.ncbi.nlm.nih.gov/25170798/

Cigarette smoking promotes acid reflux through multiple mechanisms including reduced lower esophageal sphincter pressure, increased transient sphincter relaxations, impaired esophageal clearance, and decreased saliva production

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The notable binding affinity (6.90 kcal/mol) with the replicase protein likely arises from interactions between the ligand and the viral protein, potentially inhibiting viral replication and spread 67,68