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As a stimulant, nicotine causes an increase in your blood pressure and heart rate and a narrowing of your blood vessels, which can cause poor blood circulation

Public Health 80 , 537540 (1990)
Making hospitals in China smoke-free: a prospective study of implementing the new standard

PubMed Central , Get to Know an Enzyme: CYP1A2 | Pharmacy Times

Tobacco companies have increasingly marketed heated tobacco products (HTPs) under the guise of providing a healthier alternative to traditional smoking

Nicotine & Tobacco Research, 2004