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doi: 10.1016/0092-8674(77)90065-4

Hormonal imbalance, particularly during pregnancy or from contraceptives, may stimulate melanin secretion

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Inflammatory cytokines, such as IL-6, are potential markers for detecting inflammation more sensitively than body temperature and CRP levels [18, 38]

Binding of nicotine causes the release of those neurotransmitters, which accounts for diverse effects on elevating mood and producing euphoria